Endocrine Abstracts

Introduction: Childhood-onset hypopituitarism is an uncommon yet increasingly diagnosed disorder. As endocrinologists, we generally deal with the complexities of hormonal replacement and, when required, follow these patients to detect tumor recurrences. However, some causes of childhood- onset-hypopituitarism have comorbidities which can significantly increase morbi-mortality. We present the case of a 21-year-old girl who was diagnosed with ROHHAD syndrome.<p class="abstex...

Introduction: Neuroendocrine lesions in the thyroid gland are uncommon. The differential diagnosis usually includes medullary thyroid carcinoma, paraganglioma and metastases. There are few non-conclusive reports of primary neuroendocrine carcinomas of the thyroid.Clinical case: A 49-year-old woman with a past medical history for familial hypercholesterolemia and right oophorectomy for mature teratoma with struma ovarii, was evaluated for a rapidly growin...

Subcutaneous lipomas (SL) are the most common benign mesenchymal tumors with an estimated prevalence of 1%. They usually appear single, between 50–60 years of age, without gender differences. However, multiple lipomatosis (ML) occurs in 5–10% of patients, more frequently in men and almost 30% of them have family history of ML. Cytogenetic abnormalities are found in 50–80% of cases (at 12q15) and the presence of an underlying mitochondrial dysfunction has been su...

Objective: Combination with cabergoline may offer additional benefits to acromegalic patients on pegvisomant monotherapy. We evaluated the safety and efficacy profile of this combination and investigated the determinants of response.Design: An observational, retrospective, cross-sectional, registry-based study.Patients and methods: Fourteen acromegalic patients (9 females), who were partially resistant to somatostatin analogs and o...

Most kindreds of familial isolated pituitary adenomas (FIPA) with mutated AIP develop somatotropinomas, characterized by an aggressive clinical phenotype including early age at diagnosis, large tumours and frequent invasiveness. In non-family cases, the prevalence of AIP mutations in pituitary adenomas is lower than 10%. There is no information of AIP prevalence in isolated somatotropinomas characterized by poor response to conventional treatment.Aim: To...